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Swiss startup Nagi Bioscience uses in vitro testing to replace animal testing


Revolutionary technology for replacement of traditional animal testing

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Nagi Bioscience has developed an innovative “Organism-on-Chip” technology, aiming to change the way toxic and beneficial effects of substances are tested today.

This technology relies on the combined use of microfluidics and microscopic worms to provide a new sustainable alternative to traditional animal testing to pharma, chemical, cosmetic industries, and biomedical research.

Relevant industries

  • Pharma
  • Chemical
  • Biomedical
  • Health and wellness
  • Cosmetics
  • Explanations


    An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.


    Microfluidics is the science of manipulating and controlling fluids, usually in the range of microliters (10-6) to picoliters (10-12), in networks of channels with dimensions from tens to hundreds of micrometers.

    Microfluidic devices

    Microfluidic devices are used extensively in medical diagnostics and pharmaceutical testing. They are also used in biological studies, since they can operate at the level of a single cell.

    In vitro testing

    In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Also called test-tube experiments or lab testing, these studies are traditionally done in labware such as test tubes, flasks, petri dishes etc.

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    Worms in high-tech housing replace laboratory mice

    In an effort to improve drug, cosmetic and toxic product tests, Nagi Bioscience has created a device that automatically grows, feeds, houses and analyzes laboratory worms. This invention will save researchers both time and money and sharply reduce the number of tests that require laboratory mice. A prototype has already been tested and approved by several laboratories.

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    Search key words

  • Organ-on-chip
  • Microfluidics
  • Microfluidic devices
  • Alternatives to animal testing

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